Significant improvements in ADHD symptom control when used alone or when added to an existing stimulant medication based on the study results.
As an orange-flavored liquid medicine, ONYDA XR can be easier for children who have difficulty with pills. Dosing at night may also make morning routines easier.
ONYDA XR is made differently from other clonidine products! With a single night-time dose, our unique technology provides smooth, consistent release through the day.
Under the supervision of an HCP, ONYDA XR can be started at a low dose and adjusted in small increments to help find the lowest effective dose for your child. This individualized approach may help optimize treatment while minimizing side effects.
Watch Dr. Daniel Tan explain how microtitration may support personalized ADHD treatment.
Watch videos with physicians and patients on the impact of ADHD.
We want to make getting ONYDA XR as easy and inexpensive as possible! Learn about your options below!
8 out of 10 of commercially covered patients pay $25‡
Or text TRIS to TRIS4U (874748) for a Mobile Savings Card§
You’ll also receive free delivery, automatic refills, same-day processing, and ongoing support.
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* IQVIA® XPonent data (Percent growth 12/25 vs 3/26 and total prescriptions 11/25-1/26 vs 1-3/26) † Terms and Conditions apply. ‡ 2026 savings card data (Feb-April 2026). § Mobile Terms and Conditions: TrisSavingsCard.com/terms. Message data rates may apply. a Offer not valid for use by patients enrolled in Medicaid, TRICARE, or any other federal or state healthcare or prescription drug benefit program.
REFERENCES: 1. ONYDA XR [package insert]. Tris Pharma, Inc., Monmouth Junction, NJ. 2. Northwell Health System. The ADHD Medication Guide. ©Northwell Health, Inc. Published 2011-2015. Accessed August 27, 2025. https://www.adhdmedicationguide.com. 3. Jain R, Segal S, Kollins SH, Khayrallah M. Clonidine extended-release tablets for pediatric patients with attention-deficit/hyperactivity disorder. J Am Acad Child Adolesc Psychiatry. 2011 Feb;50(2):171-9. 4. Kollins SH, Jain R, Brams M, Segal S, Findling RL, Wigal SB, Khayrallah M. Clonidine extended-release tablets as add-on therapy to psychostimulants in children and adolescents with ADHD. Pediatrics. 2011 Jun;127(6):e1406-13. 5. Rafla E, Witkovic M, Horng J, Potenziano J, Grieco J. A randomized, open label, multiple-dose, two-way study to evaluate bioavailability of clonidine HCl extended-release oral suspension compared to clonidine HCl extended-release tablets. Poster presented at: Psych Congress; October 29 - November 2, 2024; Boston, MA. 6. Tan, D., & King, T. R. (2022). Finding the “sweet spot”: Sharing the decision-making in ADHD treatment selection. Annals of General Psychiatry, 21(14). https://doi.org/10.1186/s12991-022-00394-2.
ONYDA XR is a prescription medicine used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD) alone or with certain other ADHD medicines in children 6 years of age and older.
It is not known if ONYDA XR is safe and effective in children under 6 years of age.
ONYDA® XR (clonidine HCI) is a prescription medicine used for the treatment of Attention Deficit Hyperactivity Disorder (ADHD), alone or with certain other ADHD medicines, in children 6 years of age and older. It is not known if ONYDA XR is safe and effective in children under 6 years of age.
Do not take ONYDA XR if you are allergic to clonidine.
Before taking ONYDA XR, tell your healthcare provider if you have kidney problems; low or high blood pressure; a history of passing out (syncope); heart problems (including slow heart rate or rhythm problems); had a stroke or stroke symptoms; or had an allergic reaction after taking clonidine through the skin (patch). Tell your healthcare provider if you are pregnant, planning to become pregnant, or breastfeeding. It is not known if ONYDA XR may harm an unborn baby. ONYDA XR passes into breast milk and may cause sleepiness, floppy muscles, or breathing problems in breastfed babies. A pregnancy registry is available at 1-866-961-2388 or womensmentalhealth.org/adhdmedications.
Tell your healthcare provider about all medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ONYDA XR may interact with medicines for depression, ADHD, heart or blood pressure conditions, medicines that cause sleepiness, or other clonidine-containing medicines.
What to avoid while taking ONYDA XR?
Avoid dehydration and overheating, which may increase the risk of passing out.
Do not drive, operate machinery, or perform dangerous activities until you know how ONYDA XR affects you, because it may cause sleepiness and tiredness that can slow reaction times.
Avoid alcohol or other medicines that cause sleepiness or dizziness unless discussed with your healthcare provider.
Do not suddenly stop ONYDA XR. Stopping suddenly may cause rebound high blood pressure and withdrawal symptoms. Contact your healthcare provider before stopping treatment. If vomiting prevents you from taking ONYDA XR, contact your healthcare provider because rebound hypertension may occur.
Possible side effects
ONYDA XR may cause serious side effects including:
Low blood pressure and slow heart rate, which may increase the risk of passing out. Your healthcare provider should check your heart rate and blood pressure before and during treatment.
Sleepiness and tiredness that may slow reaction times.
Rebound high blood pressure and withdrawal symptoms after sudden stop (including headache, increased heart rate, nausea, flushing or warm feeling, lightheadedness, chest tightness, nervousness, or anxiety).
Allergic reactions. Stop taking ONYDA XR and seek medical help immediately if you develop rash, hives, or swelling of the eyes, face, lips, or tongue, especially if you previously had an allergic reaction to clonidine patch.
ONYDA XR may cause fertility problems in females and males, which may affect the ability to have a child. Talk to your healthcare provider if this is a concern.
Most common side effects when used alone:
Sleepiness/tiredness, nightmare, constipation, irritability, trouble sleeping, and dry mouth.
Most common side effects when used with other ADHD medicines:
Sleepiness/tiredness, decreased appetite, and dizziness.
These are not all possible side effects of ONYDA XR. Call your healthcare provider for medical advice about side effects. Report side effects to Tris Pharma, Inc. at 1-732-940-0358 or FDA at 1-800-FDA-1088.
Please see Full Prescribing Information and Patient Information, including Instructions for Use.
Please see Full Prescribing Information, including BOXED WARNING regarding ABUSE, MISUSE, and ADDICTION (for relevant products).
DXR.EN.3338.PR 10/25
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